The Big Blindside Theory managed a twelve-season run, and over that time, most of the main characters inverse and then much that they became almost unrecognizable. While some didn't take a huge arc, others changed careers, got married, had kids, fifty-fifty went to infinite... and of course, for Sheldon and Amy, won a Nobel Prize.

In that location are lots of ways to look at the changes that the characters underwent in the series, but one that can be surprisingly revealing is to look at the first and final line they spoke. While some finish upwards being unimportant, the majority actually go a long way to revealing how they were first introduced, what changed, and what echoes of their early selves can exist found in the later moments.

10 Beverly Hofstader

Yeah, I tin can read the sign, I'chiliad just pondering the implications. - You, forgiving me. It means a lot. Thank you.

Leonard's relationship with his mother was never easy. In earlier seasons, fans observe out that as a child, she was painfully cold and distant (and so much so that he created a 'hugging motorcar' for himself). She treated her children like experiments, and despite Leonard'southward incredible intelligence and success, he idea she saw him as an underachiever. Notwithstanding, by the end, a lot more of her humanity, her ain foibles, and her motivations have been revealed, making her significantly more sympathetic. Her first and last lines show this, every bit she starts out painfully clinical in her first interaction with Penny, and ends upward quite emotional, thanking Leonard for his forgiveness.

9 Leslie Winkle

Hi Leonard. Goggles, Leonard. - Happy Altogether Dumbass

Leslie's beginning line is a bit of a non-starter, as she is just greeting Leonard. The rest of their interaction is significantly improve, every bit Leonard is struggling to ask Leslie out, and she's trying to rut upwards a cup'o'noodles with a high-powered laser, but her technical first line is a bit of a dull one. Of course, their relationship isn't actually developed on the evidence, either, equally Leslie exists largely to create a picayune drama. Her last line is really part of a larger, and more telling speech at Sheldon's birthday - i that starts past saying she would usually say 'Happy Birthday, dumbass', but she has grown and changed. Of grade, as usual, Leslie is played for laughs, equally Sheldon thanks her and asks her to say it anyway.

viii Stuart Bloom

Oh, hey Leonard. Can I help yous find something? - Speaking of which, where exercise yous keep the spaghetti strainer?

For potentially the nearly uncertain of the characters, it's noteworthy that both his offset and last lines are questions. While Stuart goes through some major changes on the show, he really never develops any conviction in himself. Across that, these 2 lines also prove how important he becomes to the group over the grade of the series.

Initially, he and Leonard have a friendly relationship, just information technology'due south still quite distant and clearly that of a customer/business owner. By the end, he is taking intendance of Howard and Bernadette's kids, and request them nigh a spaghetti strainer to help potentially find something that was swallowed... certainly not distant whatsoever more!

vii Bernadette Rostenkowski

Microbiology.  - She savage down the stairs? Oh Stuart!

Neither Bernadette's first or final line holds up well on its ain, which is a shame for such an incredible character. Her starting time line is in response to a question from Howard on their beginning blind engagement, when he asks what she is studying (and then makes a bad joke, which falls flat). Her last line is too a response, this time to Stuart, who is looking later her kids and tells her that her girl cruel downwardly the stairs and lost a tooth.

six Howard Wolowitz

Wait till you see this! - I wasn't sure what to exercise, now I am. Nosotros're going home.

Howard'southward first line comes when he is walking into the apartment with Raj, and the two of them are excited near telling Leonard something. His last line comes when he and Bernadette are with the gang to watch Sheldon and Amy get their Nobel Prize, and they are freaking out about being away from the kids. He tells Sheldon this, and Sheldon replies with his usual selfishness, leading Howard to say they are going habitation. (Spoilers, they don't).

While these may seem similar fairly 'nothing' lines, they actually say a lot about how Howard has grown. Initially, he is always with Raj, and the two basically have a articulation start line. By the end, though, his priority is Bernadette and his family. In addition, in the early seasons, Howard was cowed past Sheldon... but finally, by the end, he tin stand to him.

5 Raj Koothrappali

Information technology's fantastic! Unbelievable! - I know.

Raj, sadly, is the only 1 of the main group who doesn't achieve his goals. Anybody else gets married, but despite his desperation to find honey, Raj ends up alone (admitting sitting adjacent to Sarah Michelle Gellar). Howard goes to space, Bernadette and Penny launch careers, Amy and Sheldon win a Nobel Prize, but Raj... basically stays the same.

Which may exist why his lines are then... ho-hum. His first line is a follow up to Howard's, and really just echoes the best friend he was constantly with for the first several seasons. His last line is a throwaway joke with Sarah Michelle Gellar, which is sad to meet. The line itself may be funny, but Raj deserved more.

four Amy Farrah Fowler

Excuse me, I'g Amy Farrah Fowler, you lot're Sheldon Cooper. - And now, speaking of not listening, my husband, Dr. Sheldon Cooper

Amy Farrah Fowler's introduction to the series was amazing, every bit she and Sheldon end upward on a blind date thanks to a website that Howard and Raj prepare Sheldon's contour on. Their initial engagement sees Amy interim almost exactly the same as Sheldon, showing what a perfect pair they really are. And although Amy grows, and slowly reveals that she is much more complex and less of a Sheldon-clone than nosotros saw at starting time, she is still a perfect lucifer for him... equally shown past her final line, referring to Sheldon as her husband. Of course, the lines that come earlier this are actually significantly more meaningful, as Amy gives her Nobel Prize acceptance spoken language, encouraging young women to go into the sciences.

3 Leonard Hofstadter

Agreed. What's your point? - How long is it going to take you to get set up?

Leonard'south anxiety and doubt is one of his defining traits, so perhaps it is no surprise that his offset and concluding lines (like Stuart's) are both questions. His kickoff is to Sheldon, equally Sheldon tells him about the famous 'Double Slit' experiment, and he asks what Sheldon'southward point is (turns out, he doesn't have one, but thinks information technology would be a cool t-shirt). In the end, he is asking a pregnant Penny struggling with morn sickness virtually how long she will take. The biggest takeaway here, though, is that Leonard's focus has shifted - from Sheldon to Penny.

2 Penny

Oh, hullo! That's squeamish.  -  Thanks Sheldon, I haven't told my parents yet, but thanks.

Penny's beginning lines are when she initially meets Sheldon and Leonard... and at that place are a few more than 'hi!'due south in there, too. She seems distant just pleasant, and the gag here is really all about Sheldon and Leonard. In the finish, though, she gets a sugariness callout in Sheldon'due south speech, and thanks him for his kind words.

One of the more interesting things nigh this is really that Sheldon's spoken communication to Leonard and Penny includes a callback to that same scene, simply a little later on. Sheldon reminds them that Leonard, who falls for Penny immediately, says that their 'children will exist smart and beautiful'... and now that Penny is pregnant, he is sure that volition be true.

1 Sheldon Cooper

If a photon is directed through a aeroplane with two slits in it, and either slit is observed, it will non go through both slits. - I apologize if I haven't been the friend you deserve, but I want y'all to know, in my way I love yous all. And I love you. Thank y'all.

Unsurprisingly, Sheldon's first and last lines are big ones. His first line is the start of an explanation of the 'Double Slit Experiment' - an experiment that is well known to anyone with an involvement in physics, but does double-duty of sounding wildly circuitous and scientific to anyone else. It sets the tone for the prove, and the character, nicely. His final line, though, is at the end of a final spoken language which is long and heartfelt, individually thanking all his friends for all that they have done for him. It's a perfect mode to evidence how much he's grown.

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